Glycogen synthase kinase-3 and its inhibitors: Potential target for various therapeutic conditions

A Prasanth Saraswati; S M Ali Hussaini; Namballa Hari Krishna; Bathini Nagendra Babu; Ahmed Kamal

doi:10.1016/j.ejmech.2017.11.103

Glycogen synthase kinase-3 and its inhibitors: Potential target for various therapeutic conditions

Eur J Med Chem. 2018 Jan 20:144:843-858. doi: 10.1016/j.ejmech.2017.11.103. Epub 2017 Dec 9.

Authors

A Prasanth Saraswati¹, S M Ali Hussaini², Namballa Hari Krishna³, Bathini Nagendra Babu¹, Ahmed Kamal⁴

Affiliations

¹ Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad, 500 037, India.
² Medicinal Chemistry & Pharmacology, CSIR-Indian Institute of Chemical Technology, Hyderabad, 500 007, India.
³ Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad, 500 037, India; Medicinal Chemistry & Pharmacology, CSIR-Indian Institute of Chemical Technology, Hyderabad, 500 007, India.
⁴ Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad, 500 037, India; Medicinal Chemistry & Pharmacology, CSIR-Indian Institute of Chemical Technology, Hyderabad, 500 007, India; School Pharmaceutical Education and Research (SPER), Jamia Hamdard, New Delhi 110062, India. Electronic address: ahmedkamal@iict.res.in.

PMID: 29306837
DOI: 10.1016/j.ejmech.2017.11.103

Abstract

Glycogen Synthase Kinase-3 (GSK-3) is a serine/threonine kinase which is ubiquitously expressed and is regarded as a regulator for various cellular events and signalling pathways. It exists in two isoforms, GSK-3α and GSK-3β and can phosphorylate a wide range of substrates. Aberrancy in the GSK-3 activity can lead to various diseases like Alzheimer's, diabetes, cancer, neurodegeneration etc., rendering it an attractive target to develop potent and specific inhibitors. The present review focuses on the recent developments in the area of GSK-3 inhibitors and also enlightens its therapeutic applicability in various disease conditions.

Keywords: Alzheimer's; Cancer; Diabetes; GSK-3 inhibitors; Neurodegeneration.

Publication types

Review

MeSH terms

Alzheimer Disease / drug therapy
Alzheimer Disease / metabolism
Antineoplastic Agents / chemistry
Antineoplastic Agents / pharmacology*
Diabetes Mellitus / drug therapy
Diabetes Mellitus / metabolism
Glycogen Synthase Kinase 3 / antagonists & inhibitors*
Glycogen Synthase Kinase 3 / metabolism
Humans
Hypoglycemic Agents / chemistry
Hypoglycemic Agents / pharmacology*
Neoplasms / drug therapy*
Neoplasms / metabolism
Neurodegenerative Diseases / drug therapy
Neurodegenerative Diseases / metabolism
Neuroprotective Agents / chemistry
Neuroprotective Agents / pharmacology*
Protein Kinase Inhibitors / chemistry
Protein Kinase Inhibitors / pharmacology*

Substances

Antineoplastic Agents
Hypoglycemic Agents
Neuroprotective Agents
Protein Kinase Inhibitors
Glycogen Synthase Kinase 3